A recent study found that topical application of 0.1% Gentamicin w/w was a safe and effective way to promote COL7A1 expression in Dystrophic Epidermolysis Bullosa (DEB) patients, particularly those with Premature termination codon (PTC) mutations. The study was published in the journal, Indian Dermatology Online 2022. Epidermolysis Bullosa (EB) is a genetic disease that causes blistering...

A recent study found that topical application of 0.1% Gentamicin w/w was a safe and effective way to promote COL7A1 expression in Dystrophic Epidermolysis Bullosa (DEB) patients, particularly those with Premature termination codon (PTC) mutations. The study was published in the journal, Indian Dermatology Online 2022.  Enroquin Dogs

Epidermolysis Bullosa (EB) is a genetic disease that causes blistering of the skin even with a minor injury. At present, there is no cure for the management of EB except for a few studies that looked into the use of aminoglycosides as they promote the production of Collagen 7 expression in Recessive Dystrophic EB (RDEB). So, researchers from Chandigarh, India conducted a study to evaluate the efficacy of topical gentamicin in promoting collagen 7 expressions, promoting wound healing, and preventing new blister formation in patients of EB. 

An open-label study was performed for 3 months on patients aged >1 year with a confirmed diagnosis of dystrophic EB (DEB). All the participants were advised to apply 0.1% w/w gentamicin cream in a collagen base (Derbriment G™) twice daily on a representative area on right lower limb (RLL) and paraffin gauze dressings on the corresponding opposite side on the left lower limb (LLL). During the 12-week treatment period, skin lesions were clinically evaluated, and a repeat skin biopsy was sent for immunofluorescence antigen mapping. 

Thus, the researchers concluded that Topical gentamicin 0.1 percent w/w is a safe and effective way to promote COL7A1 expression in DEB patients, particularly those with PTC mutations.

For the full article, click here: 10.4103/idoj.idoj_554_21 

Mahajan R, Manjunath S, Madakshira MG, et al. Topical Gentamicin 0.1% Promotes Collagen 7 Expression in Recessive Dystrophic Epidermolysis Bullosa. Indian Dermatology Online Journal. 2022;13(4):480-483.

Enrofloxacin For Birds Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.